Do you have a hard time saying no to new activities even when you are already feeling frazzled and overscheduled?  Maybe you have a hard time saying no because you like to help others.  Or, maybe it's because you don't want to disappoint others.  Or, maybe you want others to like you.  Regardless of why you have a hard time saying no, you can make it easier to do by changing your perspective.  Instead of thinking about saying no as disappointing others or feeling like they might get upset with you.  Think about saying no to things that don't align with your values and goals as freeing up more time and energy to say yes to the best opportunities that do align with your values and goals.  You only have one life.  As Steve Jobs reminds us, "You have to pick carefully".